NEJM published a study regarding appropriate MAP among patients with septic shock. Originally MAP of 65 was a target but the Surviving Sepsis Campaign guideline was recommending patients with HTN, may have benefit for higher MAP. In this study 776 patients with septic shock during resuscitation targeted MAP of 65- 70 mm Hg vs 80-85 mm Hg. No significant mortality was found between these groups at 28 days and 90 days. They found higher rate of new atrial fibrillation among higher MAP group(80-85). Conclusions is “Targeting a mean arterial pressure of 80 to 85 mm Hg, as compared with 65 to 70 mm Hg, in patients with septic shock undergoing resuscitation did not result in significant differences in mortality at either 28 or 90 days”.