What is your choice to treat chronic joint pain? I know! It is very frustrating for patients and physicians, I took 800mg of Motrin but… and you know Narcotics wont do anything with pain. Lancet in a meta-analysis compared NSAIDs, Acetaminophen, or placebo. They concluded that Diclofenac 150 mg/day is the most effective NSAID available at present. This dose is more than usual dose that we are practicing, Diclofenac for osteoarthritis is 35 mg / tid. The safety of using it with that dose and also with GI/PUD, and cardiovascular disease should be considered.