{"id":1246,"date":"2026-05-14T21:56:06","date_gmt":"2026-05-15T01:56:06","guid":{"rendered":"https:\/\/emeddoc.org\/?p=1246"},"modified":"2026-05-14T21:56:08","modified_gmt":"2026-05-15T01:56:08","slug":"amoxi-or-amoxi-clavulanate-for-acute-sinusitis","status":"publish","type":"post","link":"https:\/\/emeddoc.org\/?p=1246","title":{"rendered":"Amoxi or Amoxi-Clavulanate for Acute Sinusitis?"},"content":{"rendered":"\n<p>When considering oral broad-spectrum antibiotic therapy for acute sinusitis, clinicians often favor amoxicillin-clavulanate over amoxicillin alone. However, a large retrospective cohort study published in JAMA evaluated 521,244 adult patients diagnosed with acute sinusitis, of whom 65.5% were female, and found that amoxicillin alone was not associated with higher rates of treatment failure compared with amoxicillin-clavulanate. Importantly, patients treated with amoxicillin-clavulanate experienced a higher rate of adverse effects, highlighting the importance of balancing antimicrobial spectrum with potential medication-related harm and supporting more selective antibiotic stewardship practices.<\/p>\n\n\n\n<p><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2847972\" data-type=\"link\" data-id=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2847972\" target=\"_blank\" rel=\"noreferrer noopener\">Link to article<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>When considering oral broad-spectrum antibiotic therapy for acute sinusitis, clinicians often favor amoxicillin-clavulanate over amoxicillin alone. However, a large retrospective cohort study published in JAMA evaluated 521,244 adult patients diagnosed with acute sinusitis, of whom 65.5% were female, and found that amoxicillin alone was not associated with higher rates of treatment failure compared with amoxicillin-clavulanate. [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35,13,14,15,16],"tags":[],"class_list":["post-1246","post","type-post","status-publish","format-standard","hentry","category-ent","category-pgy1","category-pgy2","category-pgy3","category-pgy4"],"_links":{"self":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts\/1246","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1246"}],"version-history":[{"count":1,"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts\/1246\/revisions"}],"predecessor-version":[{"id":1247,"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts\/1246\/revisions\/1247"}],"wp:attachment":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1246"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1246"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1246"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}