{"id":1254,"date":"2026-06-13T14:27:18","date_gmt":"2026-06-13T18:27:18","guid":{"rendered":"https:\/\/emeddoc.org\/?p=1254"},"modified":"2026-06-13T14:27:22","modified_gmt":"2026-06-13T18:27:22","slug":"septic-shock-iv-fluids-or-vasopressor","status":"publish","type":"post","link":"https:\/\/emeddoc.org\/?p=1254","title":{"rendered":"Septic Shock; IV fluids or Vasopressor"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">How much fluid should we give before starting vasopressors in septic shock? Should we continue to administer large fluid boluses, or should we start vasopressors earlier without waiting to see the full response to intravenous fluids?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A recent study published in NEJM sought to answer this question by randomizing nearly 1,000 patients with septic shock to either a restrictive fluid strategy with earlier vasopressor use or a more liberal fluid strategy with later vasopressor initiation. The results are thought-provoking and may influence future practice. The investigators found that a strategy of restricted fluid administration combined with early vasopressor use did not result in more days alive and out of the hospital at 90 days compared with a strategy involving larger fluid volumes and later vasopressor administration.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2516225?query=RP&amp;logout=true\" data-type=\"link\" data-id=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2516225?query=RP&amp;logout=true\" target=\"_blank\" rel=\"noreferrer noopener\">Link to article<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>How much fluid should we give before starting vasopressors in septic shock? Should we continue to administer large fluid boluses, or should we start vasopressors earlier without waiting to see the full response to intravenous fluids? A recent study published in NEJM sought to answer this question by randomizing nearly 1,000 patients with septic shock [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20,13,14,15,16,11],"tags":[],"class_list":["post-1254","post","type-post","status-publish","format-standard","hentry","category-infectious-disease","category-pgy1","category-pgy2","category-pgy3","category-pgy4","category-sepsis"],"_links":{"self":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts\/1254","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1254"}],"version-history":[{"count":1,"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts\/1254\/revisions"}],"predecessor-version":[{"id":1255,"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts\/1254\/revisions\/1255"}],"wp:attachment":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1254"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1254"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1254"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}