{"id":286,"date":"2012-03-01T01:44:31","date_gmt":"2012-03-01T06:44:31","guid":{"rendered":"http:\/\/emeddoc.org\/?p=286"},"modified":"2012-03-01T01:44:31","modified_gmt":"2012-03-01T06:44:31","slug":"intramuscular-versus-intravenous-therapy-for-prehospital-status-epilepticus","status":"publish","type":"post","link":"https:\/\/emeddoc.org\/?p=286","title":{"rendered":"Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus"},"content":{"rendered":"<p>This study is interesting because Maryland EMS has a protocol to give Midazolam IM in prehospital setting. The New England journal published on Feb,16, 2012 a double-blind, randomized study comparing IM Midazolam versus IV Lorazepam for children and adults in status epilepticus. <!--more-->The\u00a0 median times to active treatment were <strong>1.2 minutes<\/strong> in the IM-Midazolam group and <strong>4.8 minutes<\/strong> in the  intravenous-lorazepam group(make sense due to to longer period of time to get IV access), with corresponding median times from active  treatment to <strong>cessation of convulsions of 3.3 minutes and 1.6 minutes.<\/strong> Adverse-event rates were similar in the two groups.<\/p>\n<p>The conclusion is in status epilepticus, IM-Midazolam is at least as safe and  effective as IV-Lorazepam for prehospital seizure cessation.<\/p>\n<p><a href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1107494\">Link to Article<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This study is interesting because Maryland EMS has a protocol to give Midazolam IM in prehospital setting. The New England journal published on Feb,16, 2012 a double-blind, randomized study comparing IM Midazolam versus IV Lorazepam for children and adults in status epilepticus.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13,14,15,16,26],"tags":[],"class_list":["post-286","post","type-post","status-publish","format-standard","hentry","category-pgy1","category-pgy2","category-pgy3","category-pgy4","category-seizure"],"_links":{"self":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts\/286","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=286"}],"version-history":[{"count":2,"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts\/286\/revisions"}],"predecessor-version":[{"id":288,"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts\/286\/revisions\/288"}],"wp:attachment":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=286"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=286"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}