{"id":519,"date":"2014-04-29T16:37:00","date_gmt":"2014-04-29T20:37:00","guid":{"rendered":"http:\/\/emeddoc.org\/?p=519"},"modified":"2014-04-29T16:37:00","modified_gmt":"2014-04-29T20:37:00","slug":"biphasic-allergic-reaction","status":"publish","type":"post","link":"https:\/\/emeddoc.org\/?p=519","title":{"rendered":"Biphasic allergic reaction"},"content":{"rendered":"<p>We are usually observing patients in emergency department in length due to biphasic reaction. There are 2 articles published during last 6 months and they emphasized regarding of\u00a0 how common is biphasic reaction and mortality of this reaction!<!--more--><\/p>\n<p>The first one published in annals of EM in Nov 2013 tiltled: &#8220;<span class=\"highlight\">Incidence<\/span> of <span class=\"highlight\">Clinically<\/span> <span class=\"highlight\">Important<\/span> <span class=\"highlight\">Biphasic<\/span> <span class=\"highlight\">Reactions<\/span> in <span class=\"highlight\">Emergency Department<\/span> <span class=\"highlight\">Patients<\/span> With <span class=\"highlight\">Allergic Reactions<\/span> or <span class=\"highlight\">Anaphylaxis<\/span>&#8220;. Their objective was questionable rate of bipasic reaction and also prolong ED LOS. They Reviewed\u00a02,819 patients,\u00a0496 anaphylactic and 2,323 <span class=\"highlight\">allergic reactions<\/span>. among these 185 patients returned at least 1 time to ED related to allergic complaints. among these 5 had significant <span class=\"highlight\">biphasic<\/span> <span class=\"highlight\">reactions<\/span>. 2 of anaphylaxis group(496)\u00a0 happened in ED(16, 200 min), and 3 among allergic reaction(2323). none happened in ED. almost 6 % returned to ED with related &#8220;allergic&#8221; symptoms. Their conclusion is biphasic reaction and fatality are rare and it is not necessary in simple, uncomplicated cases to observe patient in length in ED.<\/p>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24239340\">Link to article<\/a><\/p>\n<p>The Second study was published in Allergy Apr. 2014. The objectives are\u00a0 the rate of <span class=\"highlight\">biphasic<\/span> &#8211; andit&#8217;s importance and\u00a0 anaphylactic <span class=\"highlight\">reactions<\/span>, transfers to ICU, and deaths within 10\u00a0days of presentation to the ED. Study Period from 2001 to 2013.\u00a0 From 1334, 532 allergic reaction and 495 <span class=\"highlight\">patients had anaphylactic reaction. In 227 (44.8%) the LOS was \u22658\u00a0h.\u00a0 507 uniphasic and 25 (4.5%) <span class=\"highlight\">biphasic<\/span>. 12 (2.3%) were <span class=\"highlight\">clinically<\/span> <span class=\"highlight\">important<\/span>, including 2 (0.36%) that occurred during <span class=\"highlight\">hospital<\/span> stay, one of whom (0.19%) was transferred to ICU for shock. No risk factors for <span class=\"highlight\">biphasic<\/span> <span class=\"highlight\">reactions<\/span> could be found. No death within 10 days. Their conclusion is &#8220;to consider discharging <span class=\"highlight\">patients<\/span> after complete resolution of an anaphylactic reaction and to dispense with prolonged monitoring&#8221;.<br \/>\n<\/span><\/p>\n<p><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.12404\/pdf\">\u00a0Link to article<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We are usually observing patients in emergency department in length due to biphasic reaction. There are 2 articles published during last 6 months and they emphasized regarding of\u00a0 how common is biphasic reaction and mortality of this reaction!<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27,13,14,15,16,1],"tags":[],"class_list":["post-519","post","type-post","status-publish","format-standard","hentry","category-anaphylaxis","category-pgy1","category-pgy2","category-pgy3","category-pgy4","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts\/519","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=519"}],"version-history":[{"count":6,"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts\/519\/revisions"}],"predecessor-version":[{"id":525,"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts\/519\/revisions\/525"}],"wp:attachment":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=519"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=519"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=519"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}