{"id":687,"date":"2015-08-12T14:58:58","date_gmt":"2015-08-12T18:58:58","guid":{"rendered":"http:\/\/emeddoc.org\/?p=687"},"modified":"2015-08-12T15:10:36","modified_gmt":"2015-08-12T19:10:36","slug":"tolerability-of-aztreonam-and-carbapenems-in-patients-with-ige-mediated-hypersensitivity-to-penicillins","status":"publish","type":"post","link":"https:\/\/emeddoc.org\/?p=687","title":{"rendered":"Can we give  carbapenems in patients with penicillins allergies?"},"content":{"rendered":"<p>You have a septic patient with PCN allergies! and now you are in trouble to start appropriate antibiotics due to cross reactivity. This is an Italian based study, that studied the cross-reactivity and<\/p>\n<p><!--more--><\/p>\n<p>tolerability of aztreonam and imipenem-cilastatin, meropenem, and ertapenem among\u00a0 patients with documented IgE-mediated hypersensitivity to penicillins.\u00a0 They enrolled 212 patients with immediate reactions to <span class=\"highlight\">penicillins and positive results on skin tests to penicillin reagent underwent skin tests with aztreonam and carbapenems. All subjects displayed negative skin test results to both aztreonam and carbapenems. The conclusion is: <\/span>These data indicate the <span class=\"highlight\">tolerability<\/span> of both <span class=\"highlight\">aztreonam<\/span> and <span class=\"highlight\">carbapenems<\/span> in penicillin-allergic subjects.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov.proxygw.wrlc.org\/pubmed\/?term=Tolerability+of+aztreonam+and+carbapenems+in+patients+with+IgE-mediated+hypersensitivity+to+penicillins.\">Link to article:<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>You have a septic patient with PCN allergies! and now you are in trouble to start appropriate antibiotics due to cross reactivity. This is an Italian based study, that studied the cross-reactivity and<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27,13,14,15,16],"tags":[],"class_list":["post-687","post","type-post","status-publish","format-standard","hentry","category-anaphylaxis","category-pgy1","category-pgy2","category-pgy3","category-pgy4"],"_links":{"self":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts\/687","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=687"}],"version-history":[{"count":3,"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts\/687\/revisions"}],"predecessor-version":[{"id":690,"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts\/687\/revisions\/690"}],"wp:attachment":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=687"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=687"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=687"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}