{"id":944,"date":"2019-11-29T19:46:56","date_gmt":"2019-11-30T00:46:56","guid":{"rendered":"http:\/\/emeddoc.org\/?p=944"},"modified":"2019-11-29T19:49:12","modified_gmt":"2019-11-30T00:49:12","slug":"seizure-therapy-if-benzo-fails","status":"publish","type":"post","link":"https:\/\/emeddoc.org\/?p=944","title":{"rendered":"Seizure Therapy if Benzo fails!"},"content":{"rendered":"\n<p>We know the first approach to seizure usually is<strong> <\/strong>benzodiazepines after ABC, but in status epiliepticus we should start another agent to control patient&#8217;s seizure activity that does not stop or have a breakthrough. NEJM in a RCT of 3 AED reported that levetiracetam, fosphenytoin, and valproate each:<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>could stop seizure activity in half of  patients who did not respond to benzo.<\/li><li>could improve alertness within 60 minutes<\/li><li>same adverse effect among aformentioned medication<\/li><\/ol>\n\n\n\n<p><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1905795\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\">Link to Abstract<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>We know the first approach to seizure usually is benzodiazepines after ABC, but in status epiliepticus we should start another agent to control patient&#8217;s seizure activity that does not stop or have a breakthrough. NEJM in a RCT of 3 AED reported that levetiracetam, fosphenytoin, and valproate each: could stop seizure activity in half of [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13,14,15,16,26],"tags":[],"class_list":["post-944","post","type-post","status-publish","format-standard","hentry","category-pgy1","category-pgy2","category-pgy3","category-pgy4","category-seizure"],"_links":{"self":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts\/944","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=944"}],"version-history":[{"count":3,"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts\/944\/revisions"}],"predecessor-version":[{"id":947,"href":"https:\/\/emeddoc.org\/index.php?rest_route=\/wp\/v2\/posts\/944\/revisions\/947"}],"wp:attachment":[{"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=944"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=944"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/emeddoc.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=944"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}