This is a very routine practice in ED, “I’ll be more comfortable to give one dose of Abx and then send him/her home” I did not know where this quote came from. I searched Pubmed and found this article: Antibiotic use in the emergency department. IV: Single-dose therapy and parenteral-loading dose therapy. J Emerg Medicine in 1996!!! This is the only review on this topic without any supporting good data. Am J of EM published a new study regarding one dose abx use in ED before discharging patient. This study shows one dose of abx use in ED prior to discharge was associated with higher rates of antibiotic associated diarrhea and also c-diff diarrhea! in this study 18% of pts had antibiotic associated diarrhe and 1% c-diff, now its time to think what is benefit of one dose abx IV vs risk of diarrhea to practice this kind of medicine!