Annals of Internal Medicine published a Multicenter, Double-Blind, Randomized Trial and compared Oral Prednisolone in the Treatment of Acute Gout. Patients were randomly assigned in a 1:1 ratio to receive either indomethacin or prednisolone for 5 days. The regimen was for patients presented to the ED within 3 days of symptom onset.
- Indomethacin group: patients received 50 mg (two 25-mg tablets) of the drug three times a day for 2 days, followed by 25 mg of Indomethacin three times a day for 3 days.
- Prednisolone group: patients initially received 30 mg (three 10-mg tablets) of oral prednisolone once a day for 5 days.
The conclusion is Oral prednisolone and indomethacin had similar analgesic effectiveness among patients with acute gout. Prednisolone could be the first line of treatment in acute gout.