Clindamycin vs Trimethoprim-sulfamethoxazole for Wound Infection

Infectious Disease PGY1 PGY2 PGY3 PGY4

We discussed this in 2015, but new study in Clinical Infectious Dis. again recommends antibiotic use in uncomplicated wound infection. They do not give an exact meaning of uncomplicated wound infection but we can say whenever physician meant to treat wound infection! This is a randomized, double-blind study at 5 US emergency departments. Patient  received oral clindamycin 300 mg 4 times daily or TMP-SMX 320 mg/1600 mg (2 tab TMP-SMX DS)  twice daily, each for 7 days. They compared outcome @ 7-14 days of treatment and 6-8 weeks post treatment. The conclusion is clindamycin and TMP-SMX produce similar cure and adverse event rates among patients with an uncomplicated wound infection.


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