Mono or Dual Therapy for Cellulitis

Diabetes PGY1 PGY2 PGY3 PGY4

It is very interesting that how fast we are changing our practice lately. Still remember when we started to give double dose of TMP/SMZ plus cephalexin for cellulitis, and then we changed it to 1 dose of TMP/SMZ + cephalexin and then we doubted if cephalexin is necessary or not. JAMA published a randomized study showing “Effect of Cephalexin Plus Trimethoprim-Sulfamethoxazole vs Cephalexin Alone on Clinical Cure of Uncomplicated Cellulitis”.  496 patients received cephalexin plus trimethoprim-sulfamethoxazole vs cephalexin plus placebo in uncomplicated cellulitis. They found no difference in higher rates of clinical resolution of cellulitis, only slightly different in treating diabetic and adverse effect!


Link to article