Alpha blocker (Tamsulosin , Flomax) originally is used for medical treatment of BPH. There are growing concerns that alpha blocker can be used in treatment of ureteral stone due to same affect on bladder and prostate, relaxation of muscle fiber. The recent Cochrane database review showed that compare with Nifedipine (ca channel blocker), alpha blocker has higher stone-free rate and a shorter time to stone expulsion. They recommended this medication to adjunct pain meds for patients with ureteral stone.