Age-adjusted D-dimer is an established strategy that we use routinely in daily clinical practice. This article published in JAMA demonstrated that the use of age-adjusted D-dimer thresholds can also be expanded to the evaluation of DVT, potentially reducing unnecessary imaging, healthcare costs, and resource utilization if implemented appropriately. Link to article
Continue ReadingWhen considering oral broad-spectrum antibiotic therapy for acute sinusitis, clinicians often favor amoxicillin-clavulanate over amoxicillin alone. However, a large retrospective cohort study published in JAMA evaluated 521,244 adult patients diagnosed with acute sinusitis, of whom 65.5% were female, and found that amoxicillin alone was not associated with higher rates of treatment failure compared with amoxicillin-clavulanate. […]
Continue ReadingFollowing the release of national guidelines on the management of hypertension in adults, treatment strategies emphasize the use of combination therapy with maximally tolerated doses of first-line agents. These include thiazide diuretics, long-acting dihydropyridine calcium channel blockers such as amlodipine and nifedipine, and either angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in nonpregnant adults. Link […]
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