A pre-post study conducted in North Carolina compared multi-dose epinephrine with single-dose epinephrine in adult non-traumatic out-of-hospital cardiac arrest (OHCA) patients. The authors concluded that patients with bystander CPR and a shockable rhythm who received only a single dose of epinephrine had a higher survival rate to hospital discharge compared to those who did not receive bystander CPR and had multiple doses of epinephrine.