PCN resistant Gonorrhea

Infectious Disease PGY1 PGY2 PGY3 PGY4

MMWR in latest Grand round section discussed the options for gonorrhea treatment and their recommendation in case of  cephalosporin allergy,

From CDC Site:
Treatment for Gonorrhea at any anatomic site : a single 250 mg intramuscular dose of ceftriaxone + either 1 g of azithromycin as a single oral dose or 100 mg of doxycycline orally twice daily for 7 days. If this recommended regimen cannot be used, two alternative treatment options exist for urogenital or rectal gonorrhea:

1) if ceftriaxone is not available, clinicians can consider cefixime 400 mg as a single oral dose and either azithromycin 1 g as a single oral dose or doxycycline 100 mg orally twice daily for 7 days, or

2) if the patient is cephalosporin-allergic, clinicians can consider azithromycin 2 g as a single oral dose. If either of these two alternative regimens is prescribed, the patient should return in 1 week for a test of cure.

Link to Full Text